100 Biology Pickup Lines (With Explanations)

If you’re aiming to make a memorable impression on your crush, why not consider trying out a few biology-themed pickup lines? Biology has so many subjects, terms, and words that if you can apply some charm and wit it can be a fantastic way to break the ice or catch your crush’s attention in a lighthearted way.

Science-inspired pickup lines can also serve as a brilliant showcase of your intellect. Demonstrating your knowledge while engaging in some playful flirting can be truly appealing. Combining your scientific insight with your flirting skills might just be the irresistible combination that captures your crush’s interest.

If you’re looking for some assistance in crafting your biology pickup lines, you’re in the right place. The following compilation of funny, sometimes, cheesy, sometimes cringe pickup lines are filled with delightful, adorable, and humorous ideas that are sure to get a smile.

Biology Pickup Lines

Here’s some of the best biology pickup lines with some explanation behind them just in case you are not familiar with the concepts that make the pickup line clever. Keep in mind these should be delivered in jest and in the proper setting.

1. Do you like raisins? How do you feel about a date?

This is a playful and punny way of combining a common food item (raisins) with the idea of going on a romantic date. However, the word date is a play on words for another fruit that looks similar to a raisin.

2. You must be made of Fluorine, Iodine And Neon, because you are F-I-Ne.

The play on words here involves the word “fine,” which sounds like the chemical symbols of these elements, F-I-Ne. The speaker is using the chemical symbols of these elements to spell out the word “fine,” which is commonly used to compliment someone’s appearance or overall positive qualities.

3. If I could rearrange the periodic table, I’d put U and I together.

In this pickup line, the speaker is using the chemical symbols “U” (uranium) and “I” (iodine) to spell out the words “you” and “I.”

4. Are you made of Copper and Tellurium? Because you’re CuTe.

In the periodic table, “Cu” is the chemical symbol for copper, and “Te” is the chemical symbol for tellurium. When these symbols are combined, they phonetically spell out the word “cute.”

5. Are you a Carbon sample? Because I want to date you.

By referring to the person as a “carbon sample,” the speaker is humorously comparing them to an object of scientific analysis. The line then continues by saying “Because I want to date you!” Here, “date” is used in its romantic context, but it also alludes to the scientific practice of carbon dating, creating a clever double entendre.

6. Do you have 11 protons? Because you’re Sodium fine.

The pickup line uses the fact that sodium has 11 protons to craft a pun. The pickup line is cleverly incorporating the atomic number of sodium into a compliment. The word “Sodium” is phonetically similar to “so damn,” and “fine”.

7. Are you a cat because I’m feline a connection between us.

The humor in this pickup line arises from the clever substitution of “feline” for “feeling,” and the resulting wordplay creates a cute and light-hearted way to express romantic interest.

8. Damn, girl! Are you an ion because you are attracting me so much!

In chemistry, an ion is an atom or molecule that has gained or lost one or more electrons and therefore has a positive or negative charge. Ions with opposite charges are attracted to each other due to their electrostatic forces. The pickup line uses this scientific concept of ions being attracted to one another as a metaphor for the speaker’s strong attraction to the person they’re addressing.

9. You could be my genetic duplicate because I feel like I’ve known you forever.

In biology, a genetic duplicate refers to an individual who shares a high degree of genetic similarity with another person, typically due to being identical twins or having a close family relationship. The pickup line playfully suggests that the person addressed could be the speaker’s genetic duplicate, implying that there is an uncanny sense of familiarity and connection between them.

10. I’d ask if you’re a carbon sample, but I bet you’re way too hot to be a fossil.

Carbon dating is a method used in archaeology and geology to determine the age of organic materials by analyzing the decay of carbon isotopes. This pickup line uses the carbon dating concept and suggests that the person is too attractive to be a candidate for carbon dating (fossil).

11. You make me feel like Plasm.

“Plasm” is a playful reference to the term “cytoplasm,” which is the jelly-like substance that fills the cell and houses various cellular organelles. So this pickup line is essentially saying you make me feel like jelly.

12. Hey baby, are you up for some endothermic reactions?

In chemistry, an endothermic reaction is a type of chemical reaction that absorbs heat from its surroundings, causing a decrease in temperature. It’s a way of saying that their interaction could be as dynamic and stimulating as a chemical reaction.

13. Will you act as the lower concentration and let me diffuse into you?

Diffusion is a fundamental concept that describes how substances spread out and mix with each other. The pickup line uses the scientific process of diffusion as a metaphor for closeness and intimacy.

14. I’ll show you my substrate if you show me your active site.

In biochemistry, enzymes are proteins that catalyze (speed up) chemical reactions in living organisms. Enzymes typically have a specific region called the “active site,” where the substrate (the molecule upon which the enzyme acts) binds in order to facilitate the reaction.

The pickup line cleverly uses the concepts of substrate and active site as metaphors for two people getting to know each other on a deeper level.

15. Hey baby, how about I teach you the Sn2 mechanism and show you a backside attack?

In organic chemistry, the SN2 (substitution nucleophilic bimolecular) mechanism is a type of reaction where one molecule replaces another at a saturated carbon atom. The key feature of the SN2 reaction is that it involves a nucleophile attacking the molecule from the opposite side (backside attack) of the leaving group.

The pickup line uses the concepts of the SN2 mechanism and backside attack as a metaphor for making a bold move or proposition.

16. Are you an amino acid? Because you’re making my polypeptide chain longer and longer.

Amino acids are the building blocks of proteins, and they link together in a specific sequence to form polypeptide chains, which ultimately fold into functional protein structures. This one is a little naughty, but I think you get the picture.

17. Let me be your restriction endonuclease and I’ll give you sticky ends.

In molecular biology, restriction endonucleases (or restriction enzymes) are enzymes that can recognize specific DNA sequences and cut the DNA at those sites. When a restriction enzyme cuts DNA, it often leaves behind single-stranded regions at the ends of the DNA fragments.

These single-stranded regions are called “sticky ends” because they can readily base-pair with complementary sequences, allowing for the joining of different DNA fragments. The pickup line compares the role of a restriction endonuclease in cutting DNA and creating sticky ends to the idea of forming a connection between two individuals.

18. You are the A to my T and the C to my G.

In the context of molecular biology, DNA consists of two strands of nucleotides that are held together by hydrogen bonds between specific base pairs. Adenine (A) always pairs with Thymine (T), and Cytosine (C) always pairs with Guanine (G), forming the double-stranded helical structure of DNA.

The pickup line uses the concept of base pairing in DNA to liken the compatibility and connection between two individuals to the complementary nature of A-T and C-G base pairs.

19. You must be the Hydrogen 2 my Oxygen, because baby you make me wet.

Hydrogen (H2) and oxygen (O2) are two elements that can combine through a chemical reaction to form water (H2O). The humor and flirtatiousness in the pickup line stem from the wordplay involving “make me wet” and Hydrogen and Oxygen making water.

20. If I was endoplasmic reticulum I’d be ribbed for your pleasure.

The endoplasmic reticulum is a cellular organelle involved in various functions, including protein synthesis and lipid metabolism. In the context of this pickup line, the speaker is using wordplay with the phrase “ribbed for your pleasure.”

The phrase “ribbed for your pleasure” is often associated with certain types of condoms that have a textured surface, resembling ribs, which is meant to enhance sensation during intimate activities.

21. Will you be the adenine to my thymine? Baby lets get Mendelian beneath my beta sheets!

By referencing DNA base pairing and protein structure, the pickup line creates an analogy between biological interactions and the desire for a close, personal connection.

22. I am a microbiologist, my job involves lots of streaking, probing and mounting. I do it all with culture and sensitivity.

Streaking refers to the process of streaking a sample onto a culture medium to isolate individual bacterial colonies. Probing implies using various techniques to examine microorganisms. Mounting involves preparing microscope slides by placing a specimen on a slide and covering it with a coverslip. These words obviously have less classy meanings.

23. Babe, you’re sending out excitatory neurotransmitters and I think there is an action potential.

Neurotransmitters are chemical messengers in the brain that transmit signals between nerve cells (neurons). Excitatory neurotransmitters are those that stimulate the receiving neuron and increase the likelihood of an action potential, which is an electrical impulse that travels along the neuron. This metaphor implies that the recipient is having a stimulating and exciting effect on the speaker.

24. They say the tongue is a muscle. Mine needs a workout. You want to be my trainer?

This is basically a flirty, humorous way to ask someone to make out.

25. Would you like to go to Rome and see the Cysteine Chapel?

The pickup line cleverly substitutes “Sistine” with “Cysteine,” a term from the field of biology. Cysteine is an amino acid with a sulfur-containing side chain. It’s an important building block in protein synthesis and plays a crucial role in forming disulfide bonds that help stabilize protein structures.

26. You are the activin growth factor for my phallus.

The pickup line cleverly combines the concept of “activin growth factor” with the male anatomy, using wordplay to create a suggestive and flirty innuendo.

27. Hey baby, will a little more alcohol catalyze this reaction?

In chemistry, a catalyst is a substance that increases the rate of a chemical reaction without being consumed in the process. Alcohol is a common solvent and can also play a role as a reactant or solvent in various chemical reactions. The pickup line uses the idea of alcohol catalyzing a reaction as a metaphor for sparking a connection or chemistry between two people.

28. If you were a concentration gradient I’d go down on you.

In biology and chemistry, a concentration gradient refers to the gradual change in concentration of a substance (such as molecules or ions) within a region. It’s a fundamental concept in fields like cell biology and physiology, describing how substances move from areas of high concentration to areas of low concentration. The humor in this pickup line arises from the wordplay involving the term “go down on you.”

29. My sudden protracted cardiac arrhythmia tells me I love you.

Arrhythmia is a condition where the heart beats irregularly, too fast, or too slow. The pickup line takes this serious medical condition and uses it metaphorically to describe the speaker’s intense and unexpected emotions.

30. If my right leg is the cell wall and my left the cytoplasm, do you want to be the cell membrane?

The pickup line draws an analogy between the components of a cell and parts of the speaker’s body. The right leg is likened to the cell wall, the left leg to the cytoplasm, and the proposition is to have the other person be the cell membrane.

31. You must be auxin, because you’re causing me to have rapid stem elongation.

Auxin is a plant hormone that plays a crucial role in promoting the growth and elongation of plant stems. The person is humorously likened to auxin, implying that their presence is causing the speaker’s “stem” (a playful reference to the speaker’s body) to rapidly elongate.

32. Every time I’m around you, I go through anaerobic respiration because you take my breath away.

Anaerobic respiration is a metabolic process that occurs in the absence of oxygen. It’s a way for cells to produce energy when oxygen is limited. In this context, the line is using anaerobic respiration metaphorically to convey a sense of breathlessness or being left speechless.

33. I wish I were adenine, because then I could get paired with U.

The pickup line suggests that just as adenine and uracil naturally come together to form a functional unit in RNA, the speaker wishes to come together with the person they’re addressing to form a meaningful and complementary partnership.

34. I want to stick to you like glue-cose.

The pickup line cleverly replaces the word “close” with “glue-cose,” creating a pun that incorporates the scientific term “glucose.”

35. If you were C6, and I were H12, all we would need is the air we breathe to be as sweet as sugar.

These symbols represent the chemical elements carbon (C) and hydrogen (H) along with their respective subscripts. In the molecular formula of glucose (C6H12O6), there are six carbon atoms and twelve hydrogen atoms.

The pickup line uses a well-known idiom, “sweet as sugar,” to imply that something is very enjoyable or pleasant. In this context, it’s being used to convey the idea of a sweet and delightful connection between two people.

36. Do you like aerobic respiration as much as I do?

Aerobic respiration is a biological process in which cells convert nutrients (usually glucose) into energy (ATP) by using oxygen.

37. I also prefer my ribosomes bound tight. Spin me round with your basal body and make sure it’s turgid.

Ribosomes are cellular structures responsible for protein synthesis. In this context, the speaker is using “ribosomes bound tight” metaphorically to express a preference for close physical contact or intimacy.

38. I have a smooth endoplasmic reticulum but know I like it rough.

In a cell, the endoplasmic reticulum (ER) is a network of membranes involved in various cellular processes. It’s pretty clear what the punchline is of this pickup line.

39. Right now we’re just two RNA, but maybe we could transcribe together and become DNA.

The pickup line uses the process of transcription and the transformation from RNA to DNA as a metaphor for a deeper connection between two people.

40. Can I be your enzyme? because my active site is dying for a chemical reaction.

Enzymes are biological molecules that act as catalysts, speeding up chemical reactions in living organisms. Enzymes have a specific region called the “active site” where substrate molecules bind and undergo chemical reactions. By saying this, the speaker is playfully comparing themselves to an enzyme, suggesting that they want to play a catalytic role in the other person’s life, just like an enzyme facilitates reactions.

41. Want to be my substrate/enzyme?

In biochemistry, enzymes are proteins that facilitate chemical reactions by acting on specific molecules called substrates. Enzymes bind to substrates at their active sites, where the reaction takes place. The analogy here is comparing the interaction between two people to the relationship between an enzyme and its substrate.

42. If I were a Shwann cell, I’d squeeze around your axon and give you a fast action potential.

In the nervous system, Schwann cells are responsible for creating the myelin sheath, a protective covering, around axons (the long, slender extensions of nerve cells).

43. It’s a good thing you’ve got evaporative cooling, cause I’m going to make you sweat.

Evaporative cooling is a natural process by which a substance, usually a liquid, turns into vapor and absorbs heat from its surroundings. This process is used by organisms, including humans, to regulate body temperature.

The “I’m going to make you sweat part could be referencing an intimate act or some other activity that could cause someone to break a sweat if you know what I mean.

44. Hey baby, want to form a zygote?

This pickup line uses a playful approach to introduce the concept of forming a “zygote,” which is the initial cell formed when two gamete cells (sperm and egg) fuse during fertilization.

45. Hey baby, want to form a synapse with me and exchange neurotransmitters?

The analogy used here compares forming a romantic connection (“form a synapse”) to the biological process of neurotransmission, where signals are transmitted between nerve cells at synapses.

46. You’re like telophase, I admire your cleavage.

The word “cleavage” in this context has a double meaning. While in biology it refers to the physical process of cell division, in everyday language, it’s often associated with the neckline of clothing, especially when it reveals a bit of skin.

47. I wish I was an Ion so I could form an exothermic bond with you.

In chemistry, an ion is an atom or molecule that has gained or lost electrons, resulting in a positive or negative charge. An exothermic reaction is a chemical reaction that releases heat energy to its surroundings. the pickup line playfully suggests that the speaker wishes they could form an “exothermic bond” which implies a strong and passionate connection.

48. We can make a mess as I’ve hired some lysosomes to clean up after.

Lysosomes are cellular organelles responsible for breaking down waste and cellular debris in a cell. This pickup line suggests that because a lysosome has been hired the speaker and the person being addressed can engage in some messy fun. I think you know what that might be.

49. If I was an endoplasmic reticulum, how would you want me: smooth or rough?

The humor comes from the choice between “smooth” ER and “rough” ER. These are two types of ER. “Smooth” ER is involved in lipid metabolism and detoxification, while “rough” ER is studded with ribosomes and involved in protein synthesis. The smooth or rough choice is often suggestive of intimate activities.

50. How about me and you go back to my place and form a covalent bond?

The humor and chemistry reference come from the phrase “form a covalent bond.” In chemistry, a covalent bond is a strong chemical bond where atoms share electrons. Here, the speaker playfully suggests that forming a strong connection between them, like a covalent bond, would be a desirable outcome of spending time together.

51. Everyone knows its not the size of the vector that matters, but the way the force is delivered.

The pickup line suggests that what truly matters is not the physical size but rather the manner in which force is applied or delivered. This pickup line is similar to the common phrase that it is not the size of the male anatomy that matter but how you use it.

52. According to the second law of thermodynamics, you’re supposed to share your hotness with me.

This law states that in a closed system, the total entropy (disorder or randomness) tends to increase over time. It’s often associated with the idea that heat flows from hotter objects to cooler ones, seeking equilibrium.

The term “hotness” is used metaphorically to refer to attractiveness or physical appeal, and it plays on the temperature aspect of the second law of thermodynamics.

53. Do you want to extract some protein from my column?

A column is a common component of chromatography. In this pickup line, the speaker is using the language of chromatography metaphorically to imply an intimate interaction.

54. Hey, are you an alpha carbon, because you look susceptible to backside attack.

The “backside attack” involves a nucleophile approaching a molecule from the opposite side of a leaving group, leading to bond formation. In this pickup line, the speaker playfully suggests that the person’s appearance makes them seem receptive to a “backside attack,” implying an intimate advance.

55. Hey baby, why don’t you get your ligase working on my okazaki fragment and lengthen my strand.

In DNA replication, ligase is an enzyme responsible for sealing the gaps (nicks) between Okazaki fragments on the lagging strand. The speaker is using the term “Okazaki fragment” metaphorically to refer to a part of themselves that needs attention.

By saying “lengthen my strand,” they’re humorously suggesting that the person could extend or improve that part of them.

56. Hey, want to put your alpha helix in my beta barrel?

In biochemistry, proteins are composed of various secondary structures, including alpha helices and beta sheets. A beta barrel is another type of protein structure where beta strands fold into a cylindrical shape. The pickup line playfully suggests combining these two structures, as if they were engaging in an intimate interaction.

57. If I were a neurotransmitter, I would be dopamine so I could activate your reward pathway.

Neurotransmitters are chemicals in the brain that transmit signals between nerve cells (neurons). Dopamine is a neurotransmitter associated with the brain’s reward and pleasure system. It’s released in response to pleasurable activities and is often referred to as the “feel-good” neurotransmitter.

58. You’re hotter than a bunsen burner set to full power.

A Bunsen burner is a common laboratory tool used for heating substances in scientific experiments. By saying “you’re hotter,” the speaker is using wordplay to suggest both physical heat (temperature) and attractiveness.

59. You are the photon to my photosystem: you excite my electron until I reach my reaction center.

Photosynthesis involves capturing light energy through photons and converting it into chemical energy. A photosystem is a complex of proteins and pigments that work together to absorb and utilize light energy. By saying “you are the photon to my photosystem,” the speaker is comparing the other person to a photon, which is the fundamental unit of light.

60. We fit together like the sticky ends of recombinant DNA.

By comparing themselves to the sticky ends of recombinant DNA, the pickup line suggests that just as these molecular components fit together precisely and form strong bonds.

61. If you were oxygen, I would be an alkali metal so could get in you and explode!

In chemistry, alkali metals are highly reactive elements found in the first column of the periodic table. The “get in you and explode” part is a suggestive of the climax of an intimate act.

62. I want to work on your leucine zipper with my zinc fingers.

In molecular biology, a leucine zipper is a structural motif found in some DNA-binding proteins. By mentioning the leucine zipper, the pickup line is using wordplay and alluding to undressing the person being addressed.

63. I will fondle your vesicles while you caress my golgi body.

The pickup line humorously compares cellular processes to intimate actions between two people.

64. Will a little more alcohol catalyze this reaction?

In chemistry, a catalyst is a substance that accelerates a chemical reaction without itself being consumed in the process. The term “catalyze” here is used metaphorically to suggest that a small amount of alcohol could speed up or enhance a different kind of “reaction” – a romantic or social interaction between two people.

65. You make my anoxic sediments want to increase their redox potential.

In environmental chemistry and biology, anoxic sediments refer to areas where there is a lack of oxygen, and redox potential is a measure of the tendency of a substance to gain or lose electrons.

The pickup line metaphorically suggests that the presence of the person is so captivating that even in a situation where oxygen is lacking (anoxic sediments), there is a desire to increase the redox potential, which implies a strong attraction and excitement.

66. You must be gibberellin, because I’m experiencing some stem elongation.

Gibberellins are a group of plant hormones that regulate various growth processes, including stem elongation. In the context of this pickup line, the speaker is metaphorically comparing the person they’re addressing to gibberellin, suggesting that being around them is causing a similar effect on their male body part.

67. Can I be the phasor to your electron and take you to an excited state?

In physics, a phasor is a complex number that represents a sinusoidal function’s amplitude and phase. It’s often used to analyze the behavior of alternating current (AC) circuits. By likening themselves to a phasor, the speaker is positioning themselves as someone who can influence or interact with the other person’s “electron.”

68. If I were a Schwann cell, I’d squeeze around your axon and give you a fast action potential.

Schwann cells are a type of glial cell in the nervous system that plays a crucial role in supporting and insulating neurons. The axon is a long, slender projection of a neuron that carries nerve impulses away from the cell body.

The pickup line humorously suggests that if the speaker were a Schwann cell, they would wrap around the other person’s “axon,” which is an obvious metaphor.

69. I can’t introduce foreign bodies to my system, but for you I’ll make an exception.

This part of the pickup line refers to the immune system’s role in identifying and attacking foreign substances (antigens) that enter the body. The pickup line uses the immune system as a metaphor for being cautious and protective but allowing an exception for the person being addressed.

70. Right now we’re just two RNA, but maybe we could transcribe together and become DNA.

The pickup line starts by comparing the two individuals to RNA. RNA (ribonucleic acid) is a molecule involved in various cellular processes. In the context of the pickup line, there is an allusion of two things coming together to form one. In this context a romantic union.

71. Are you a start codon? Because you’re turning me on!

In genetics and molecular biology, a start codon is a specific sequence of three nucleotides (usually AUG) that signals the beginning of protein synthesis. This pickup line refers to the person being addressed being the catalyst for the speaker’s stimulation.

72. I’m H0m0zygous recessive. Wanna do a test cross?

In genetics, “homozygous recessive” refers to having two identical alleles for a particular gene, where both alleles are of the recessive type. A test cross is a genetic experiment used to determine the genotype of an individual with a dominant phenotype. This pickup line is an analogy for compatibility.

73. If you are X-Ray diffraction, I must be neutron diffraction, because our processes compliment each other.

X-ray diffraction and neutron diffraction are both techniques used in the field of materials science and crystallography to study the structure of materials at the atomic level. These complimentary techniques allude to being a match with the person being addressed.

74. You have 206 bones in your body…want one more?

The human body has 206 bones. The rest of the pickup line is pretty self-explanatory.

75. Like metagenomics on conventional genome sequence, you’ve showed me that there is so much more to the world than I used to see.

Metagenomics is a field of genetics that involves studying genetic material directly from environmental samples, like soil or water. This field studies a diverse array of genetic material with hidden complexity. The pickup line is alluding to the same revelatory experience applying after meeting the person being addressed.

76. When I met you, it felt like moving from two-dimensional chromatography to fluorescence-based sequencing.

Fluorescence-Based Sequencing is a more modern and sophisticated method used to determine the sequence of DNA or other molecules. comparing the experience of meeting the person to transitioning from simpler to more advanced scientific techniques, the pickup line suggests that encountering the person was like moving from a basic or ordinary state to something more intricate, intense, and enlightening.

77. Are you Broca’s Aphasia? Because you leave me speechless.

Broca’s Aphasia is a neurological condition that affects language production and comprehension.

78. Can I study for the anatomy exam with you?

The speaker is metaphorically asking if they can spend time together in a way that implies they want to learn more about the other person’s “anatomy”.

79. Every time I see you, my cardiovascular system gets all worked up.

The speaker uses the term “cardiovascular system” to refer to their heart and circulatory system. “Getting all worked up” is a colloquial expression that means becoming excited, anxious, or emotionally stirred.

80. I think my heart just lagged.

A scientific way to say my heart skipped a beat.

81. You must be a red blood cell because you take the oxygen away from my lungs straight to my heart.

The speaker is metaphorically comparing the person they’re addressing to a red blood cell, implying that just as red blood cells carry oxygen from the lungs to the heart, this person has the ability to captivate them and make their heart race.

82. If I were an enzyme, I’d be helicase so i could unpackage your genes.

Helicase is an enzyme involved in DNA replication and repair. Its main function is to “unzip” or separate the two strands of DNA by breaking the hydrogen bonds between the base pairs. The pickup line is a play on words suggesting that the speaker would like to unzip the persons jeans.

83. You must be the one for me, since my selectively permeable membrane let you through.

In biology, cell membranes are selectively permeable, meaning they allow certain substances to pass through while restricting others. This alludes to there being something special about the person being addressed in the pickup line.

84. You give me more jolt than a mitochondria!

This pickup line compares the effect of being around the person to the energetic function of mitochondria within cells.

85. You are so hot; you denature my proteins.

This pickup line equates the person’s attractiveness with the high temperature that causes protein denaturation.

86. Your infectious smile put cholera to shame.

Cholera is a bacterial infection that can spread rapidly and cause severe illness. By saying the person’s smile is more infectious than cholera, the line suggests that their smile has an incredibly positive and contagious impact.

87. Just like osteoarthritis, you’re really making me weak in the knees.

Osteoarthritis is a degenerative joint disease that can lead to joint pain and weakness, particularly in the knees. By saying the person is having a similar effect, the line humorously suggests that the speaker’s attraction to them is causing them the speaker to be weak in the knees.

88. You’re so cute you make my zygomaticus muscles contract.

The zygomaticus muscles are responsible for smiling. When they contract, they pull the corners of the mouth upward, creating a smile.

89. Did you damage my cerebellum? Because I’m falling all over the place for you.

The cerebellum is a part of the brain responsible for balance, coordination, and movement. The pickup line implies that the speaker is “falling” for the person being addressed.

90. Do you love water? That means you love 70% of me; 30% to go.

The human body is composed of approximately 60-70% water, depending on factors such as age and gender. The pickup line humorously suggests that since the person loves water, they already love a significant portion of the speaker.

91. You’re the sinoatrial node of my heart. Without you, even a defibrillator won’t save me.

The SA node is a natural pacemaker located in the heart that generates electrical impulses, initiating each heartbeat. It plays a crucial role in maintaining the heart’s rhythm.

92. Organ transplants can be very dangerous, but I’d give you my heart anytime.

The line uses a comparison with organ transplants to convey the idea of deep affection and willingness to give everything to the person.

93. Maybe you need a little vitamin me in your life.

This is a common expression if someone is deficient in a certain vitamin but in this case the speaker replaces the vitamin with the word “me”.

94. You’re just like amylase because you make everything taste sweeter.

Amylase is an enzyme that helps break down starches and complex carbohydrates into simpler sugars during the process of digestion.

95. Did you cut my phrenic nerve? Because you take my breath away.

The phrenic nerve is a crucial nerve responsible for controlling the diaphragm, the muscle that plays a central role in breathing.

96. If we were like chromosomes, you’d be my homologous pair.

In genetics, homologous chromosomes are similar in structure and carry corresponding genes. This similarity is crucial for genetic diversity and inheritance.

97. You must be the cure for Alzheimer’s, because you’re unforgettable.

Alzheimer’s disease is a neurological disorder that affects memory and cognitive functions. The setup of the pickup line suggests that the person being addressed is so memorable and unforgettable that they could serve as a “cure” for forgetfulness.

98. Are you my appendix? Cause I have a funny feeling in my stomach that makes me feel like I should take you out!

The punchline of the pickup line plays on the idea of “taking out” the appendix. However, in this context, it’s used as a double entendre.

99. My hypothalamus must be secreting serotonin because I want you!

The hypothalamus is a part of the brain that plays a crucial role in regulating various bodily functions, including emotions and mood. Serotonin is a neurotransmitter associated with feelings of happiness and well-being.

100. You must be acetylcholine, because you stimulate my PNS.

Acetylcholine is a neurotransmitter—a chemical messenger—involved in transmitting signals between nerve cells and muscle cells. It plays a crucial role in the nervous system, including the parasympathetic nervous system (PNS), which is responsible for regulating rest-and-digest functions. The abbreviation for PNS sounds like a particular part of the male anatomy.

How to use the pickup line

Now that you have a few of the pickup lines how should you use them? It should be clear after reading them that they should be used in a humorous light hearted way. These are more of a conversation starter than an actual pickup line. You want to make the sure the setting is appropriate.

Depending on your existing relationship with the person and the setting, you want to make sure you deliver the pickup line in the correct setting. If you are at work or in a similar setting, make sure you are aware of workplace harassment guidelines and make sure you have a good enough repour with someone to ensure that the pickup line will be taken in a joking flirtatious way instead of a harassing way.

If you are not sure how it will land the best bet is to not say the pickup line at all maybe tell it in the context of a story instead. This way you still get to say the pickup line, but it is in the context of a story about someone else.

You want the pickup line to show your wit and knowledge so if you think it may come off in a creepy or harassing manner just don’t say it.


I’m sure by now you have a few favorites in mind from the list and you know how you should deliver the pickup line. The next step is to gather the courage to deliver it. Just remember that you need to deliver it in the appropriate setting and in the appropriate way.

If you think it may not land well saying it directly to the person tell it in a story. I hope these pickup lines will bring laughs and further relationships with those you choose to deliver them to.

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